We used a combination of immunoprecipitation with mass spectrometry to develop an extensive protein–protein “interactome” network centered on tetraspanin CD151 in HCCLM3 cells, and identified LRP1 as an important molecular partner for CD151 with regard to metastasis of HCC [16], [17], [18], Therefore, LRP1 may play a specific role in the migration and invasion of HCC cells, probably relying on the specific molecular partner, which begs us for a closer look into the role of LRP1 in HCC. Here, CD151 is linked to hepatocellular carcinoma.