Since the expression and activation of serine proteinases, urokinase plasminogen activator (uPA), TSP-1, TSP-2 as well as the matrix metalloproteinases (MMPs) can regulate the tumor microenvironment, the function of LRP1 as an endocytic receptor for diverse extracellular mediators may represent one mechanism by which LRP1 may regulate the tumor microenvironment and involve in tumor progression and spreading. Here, THBS2 is linked to neoplasm.