Our study did not precisely address several clinical issues including: whether the Hsp20 protein is stable in the extracellular environment; whether the Hsp20 protein can be employed to treat myocardial infarction by exogenous systemic administration; and what advantage the Hsp20 protein might have over VEGF in promoting myocardial angiogenesis. The gene discussed is VEGFA; the disease is myocardial infarction.