Over the past years, our laboratory has shown that elevated intracellular Hsp20 protects hearts against various stress stimuli including myocardial ischemia/reperfusion (I/R) injury [6], isoproterenol-triggered cardiac remodeling [7], endotoxin-induced myocardial dysfunction [8], and doxorubicin cardiotoxicity [9]. Here, HSPB6 is linked to myocardial ischemia.