INS and type 2 diabetes mellitus: We used the database of the Verona Newly Diagnosed Type 2 Diabetes Study (VNDS), a cohort in which associations between common genetic variants and metabolic phenotypes have already been shown to be detectable [9], [10], possibly because of the absence of the potentially confounding effects of long-lasting antidiabetic treatments and of the limited impact of duration and severity of hyperglycemia per se on the glucose insulin homeostatic system