As shown in Fig. 2C, progressive increase in the phospho (p) -AKT, -pIKKα/β, pSTAT3, and p65 expression were observed from Group 1 to Group 3 TRAMP mice as the cancer gradually progressed from LG-PIN formation in group 1 at 4–12 week of age, HG-PIN and WD carcinoma in DLP in group 2 at 12–18 week of age, and WDC, MDC and PDC at 24–36 week of age. Here, AKT1 is linked to prostate intraepithelial neoplasia.