TGFB1 and glomerulosclerosis: In addition to a Th2-like profile and changes in ganglioside metabolism, the pathogenesis of glomerulosclerosis is also marked by the presence of the fibrogenic cytokine TGF-β, which has been implicated in podocyte apoptosis, proliferation, epithelial-to-mesenchymal transition and glomerular matrix deposition [23], [36], [37], [38].