RNF31 and adrenal cortex carcinoma: In an effort to elucidate the roles of SF-1 and RNF31 in adrenal steroidogenesis and adrenocortical carcinoma on a genome-wide level, we performed siRNA-mediated knockdown of SF-1 or RNF31 ± cAMP in the adrenocortical carcinoma cell line NCI-H295R.