Here, we designed the SVM models for advanced NPC by integrating TNM stage, tissue molecular features (nm23-H1, Pontin, cyclin D1, N-Cadherin, 14-3-3σ, Ki-67, Aurora-A, Bcl-2, Beclin 1, MMP 2, EZH2, TIMP 2, COX 2 and P27) along with EBV-related biomarkers (AER, EA-IgA and VCA-IgA), which reflected each patient tumorigenesis phenotype not only in macroscopic but also in microcosmic aspect. Here, EZH2 is linked to nasopharyngeal carcinoma.