Decreased expression of total GR mRNA is evident in the dorsolateral prefrontal cortex (DLPFC) in schizophrenia [2], [3], in the temporal cortex, hippocampus and amygdala in schizophrenia and bipolar disorder [2], [4], and in the entorhinal cortex in bipolar disorder [2]. This evidence concerns the gene NR3C1 and bipolar disorder.