CCN3 and cancer: Since the discovery of this matricellular protein, CCN3 has been implicated in an increasing number of diverse biological processes including proliferation, differentiation and angiogenesis as well as pathological conditions such as fibrosis and cancer (Perbal 2001; Brigstock 2003; Leask and Abraham 2006; Perbal 2006; Chen and Lau 2009; McCallum and Irvine 2009; Zuo et al. 2010; Kular et al. 2011).