This is in contrast to our findings in which we observed high CCN3 levels in the context of low CCN1 and CCN2 expression in bone metastatic breast cancer cells (Ouellet et al. 2011) and also contrasts with the observation that human breast cancer bone metastases that display high CCN3 mRNA expression (Zhang et al. 2009). Here, CCN2 is linked to breast carcinoma.