Nevertheless, after BMP4 exposure genes for several transcription factors implicated in establishing mouse TB stem cell self-renewal and multipotency, including CDX2, EOMES, TFAP2C and GATA3, are up-regulated within 3 h, while the mRNA for others, including ELF5, ETS2 and TEAD4, which are also expressed in undifferentiated hESC, remain expressed as the transition proceeds (Fig. 3; and unpublished data available through GEO GSE10469). The gene discussed is EOMES; the disease is tuberculosis.