PTGS2 and cancer: These and other HCMV proteins also affect several additional pathways in the cellular machinery linked to tumor biology, such as cell cycle control, enhanced proliferation and migration of the cells, stimulation of telomerase activity, induced expression of COX-2 and 5-lipoxygenase and production of prostaglandin E2, leukotriene B4, and accumulated beta cathenin with potential key functions in HCMV induced oncogenesis or cancer progression [12,15-17,25-29].