Based on the known biological and prognostic information conveyed by these IHC markers in the context of breast marker and their strong association to the histological grade in our study (see below), this factor pattern can be interpreted as representing a spectrum of "the immunohistochemical grade" (i-Grade): from the tumours with predominant expression of HR and BCL2 (i-Grade-Low) to the tumours with predominant expression of Ki67 and HIF-1α (i-Grade-High). This evidence concerns the gene MKI67 and neoplasm.