COPD exacerbations are associated with increased levels of inflammatory mediators including tumor necrosis factor-alpha (TNF-α) [76], IL-8 [76, 77], IL-6 [78], and leukotriene B4 [79] and inflammatory cells such as neutrophils [70, 77] and eosinophils [70]. Here, CXCL8 is linked to chronic obstructive pulmonary disease.