Finally, to demonstrate that NSBP1 contributes to ccRCC development in vivo, we employed xenograft nude mice model and found that NSBP1 knockdown suppressed tumor growth of ccRCC cells, indicating that NSBP1 promotes the tumorigenicity of ccRCC cells in vivo. The gene discussed is HMGN5; the disease is nonpapillary renal cell carcinoma.