BCL2 and nonpapillary renal cell carcinoma: To confirm that NSBP1 knockdown could inhibit proliferation and induce apoptosis in ccRCC cells, we examined the expression of apoptosis and cell cycle related proteins and found that Bax protein level was significantly increased while CyclinB1 and Bcl-2 protein levels were decreased in NSBP1 knockdown cells compared with control (Figure 2C).