EZR and neoplasm: The novel role of S100P in the regulation of cytoskeleton dynamics was highlighted in the pathway map (Figure 6) in which S100P was involved in the interactions with ezrin [69], a membrane/F-actin cross-linking protein implicated in tumor metastasis [70-73], and with the scaffolding protein IQGAP1 [74], known to promote cell motility and invasion [75].