IFNG and systemic lupus erythematosus: The ratio between IFN-γ and IL-6 serum levels (IFN-γ/IL-6) was significantly lower in the third compared to the first trimester (median 0.43, range 0.04 to 220.20, vs 0.71, range 0.08 to 41.00, P = 0.033) in healthy controls, but not in SLE patients (median 0.34, range 0.01 to 30.00, vs 0.43, range 0.01 to 4.63, P = n.s.)(Figure 2).