In FLS of RA also, IL-22R Ab (OD: 0.71 ± 0.03) significantly inhibited rIL-22 induced FLS proliferation (OD: 1.58 ± 0.05, p < 0.001, Friedman's ANOVA with Dunn's multiple comparison test. This evidence concerns the gene IL22RA1 and rheumatoid arthritis.