The report also showed that TGF-β, IL-6, and IL-23, which are the requisite promoters of Th17 differentiation, were found in abundance in the salivary glands of patients with SS, thus demonstrating that the microenvironment of salivary glands in patients with SS is full of factors that are known to foster local Th17 lineage polarization [22]. The gene discussed is TGFB1; the disease is synovial sarcoma.