In contrast to the clinical data suggesting that T deficiency exacerbates hypertension, T deficiency induced by orchiectomy lowers blood pressure in several experimental models of hypertension including Ang II infusion [38], DOCA-salt [54], chronic L-NAME treatment [44] and in the SPSHR [145] and SHR on either a normal salt and HS diet [146]. This evidence concerns the gene AGT and hypertensive disorder.