While ovariectomy increased arterial pressure in several animal models of hypertension including Ang II- [38,39] and DOCA- [54] infusion and the DS [113] and mRen2.Lewis [111] rats (Figure 11), ovariectomy did not raise arterial pressure in the SHR on a normal sodium chloride diet [112] or the Wistar rat treated with the nitric oxide synthase inhibitor, L-NAME [44]. The gene discussed is AGT; the disease is hypertensive disorder.