There is enough evidence to suggest that the processes of EMT can be elicited by various growth factors, such as transforming growth factor β and platelet-derived growth factor-D (PDGF-D), which is expressed in PCa tissue [69], and it was shown that over-expression of PDGF-D in PC3 cells (prostate cancer cell lines with high metastatic potential) leads to the acquisition of the EMT phenotype [69]. Here, PDGFD is linked to Familial prostate cancer.