Taking into consideration the prevalent expression of CD44 in CSCs and the role of CD44 in mediating CSC migration and homing, suggesting its role in metastasis in various malignancies including PCa whereby the role of miR-34a in controlling CSC characteristics appears to be important, and thus targeting of miR-34a pathways could become innovative treatment strategies for PCa [57]. This evidence concerns the gene CD44 and posterior cortical atrophy.