SDF-1/CXCR4 axis is involved in the promotion of angiogenesis, local cell proliferation and migration of cancer cells to the metastatic sites in many different kinds of cancers as those of breast [21,35], lung [36], ovarian [1,37], renal [38], prostate [39], and neuroblastoma [40]. Here, CXCR4 is linked to neuroblastoma.