Moreover, previous studies demonstrated that IL-8, TNF-α and NF-κB tend to increase in the peritoneal fluid according to the severity of dysmenorrhea, extent pelvic adhesion and proliferation of endometrial stroma cells, and MUC2 expression could increase accordingly via activation of NF-κB pathway through these cytokines [50-52]. This evidence concerns the gene CXCL8 and Dysmenorrhea.