In view of the importance of the suspected link between PANK2 and α-synuclein aggregation and Lewy body formation [24] and the potential association of PANK2 with tau aggregation, one of the major aims of our study was to investigate whether Lewy body or neurofibrillary tangle pathology is present in any of our genetically proven PKAN cases. The gene discussed is PANK2; the disease is pantothenate kinase-associated neurodegeneration.