Subsequently, in a detailed neuropathological study of five additional cases with PLA2G6 mutations, we also confirmed that α-synuclein deposition is a consistent phenomenon in cases with PLA2G6 mutations and also that the Lewy body pathology may be severe and extensive with a pattern similar to that seen in end-stage Lewy body disorders including dementia with Lewy bodies and Parkinson's disease [27]. The gene discussed is PLA2G6; the disease is Parkinson disease.