The results of two phase II trials were recently published, evaluating the efficacy and safety of R1507 (robatumumab, a fully human IgG1 mAb to IGF-1R) in recurrent and refractory Ewing’s sarcomas and AMG 479 (fully human mAb to IGF-1R) in recurrent refractory Ewing’s family of tumors and desmoplastic small round cell tumors (DSRT). This evidence concerns the gene IGF1R and desmoplastic small round cell tumor.