The aim of the present study was to examine the influence of IP6 on the transcriptional activity of selected MMPs of their three subgroups, i.e., MMP-1, MMP-2, MMP-3, MMP-9, MMP-10, MMP-13, and that of their TIMP-1 and TIMP-2 in human colon cancer Caco-2 cells as well as IP6 ability to affect IL-1β-influenced changes in mRNA levels of the studied genes. Here, MMP2 is linked to colonic neoplasm.