The fact that mosttumor-specific somatic mutations however seem to affect genes not expressed on thesurface membrane of cancer cells (24-27) should not matter, for such antigens couldbe effectively presented as mutant peptide/MHC molecule complexes on the surface ofcancer cells or after cross-presentation on the surface of stromal cells in thetumor (3, 28, 29). The gene discussed is HLA-C; the disease is cancer.