Nevertheless, at 210 nM in the HCT116 cell line and 94 nM in the HT29 cell line, NVP-BEZ235 completely inhibited 4EBP1 phosphorylation consistent with the inhibition induced by 100 and 500 nM NVP-BEZ235 in the H929 and OPM-2 myeloma cell lines (Baumann et al, 2009). Here, EIF4EBP1 is linked to plasma cell myeloma.