HDAC3 and malignant colon neoplasm: In a recent study in which human HCT116 colon cancer cells were treated with sulforaphane (SFN), a cancer chemoprotective agent abundant in broccoli, a link between CK2-mediated phosphorylation of HDAC3 and SMRT and the disruption of the nuclear HDAC3-SMRT corepressor complex, followed by the export of HDAC3 into the cytoplasm, was suggested [114].