RELN and bipolar disorder: In a study on mice in which the Reln promoter was hypermethylated by pretreatment with L-methionine, clozapine and sulpiride (atypical antipsychotics for schizophrenia and bipolar disorder) decreased DNA methylation at the reelin (Reln) promoter and the N-terminus of the 67 kDa glutamic acid decarboxylase (Gad67) promoter in the frontal cortex and striatum [51].