SETD2 and nonpapillary renal cell carcinoma: The histone modifying enzymes directly involved in ccRCC development are SET domain containing 2 (SETD2), a histone H3 lysine 36 methyltransferase, Jumonji/ARID domain-containing protein 1C (JARID1C), a histone H3 lysine 4 demethylase and ubiquitously transcribed X chromosome tetratricopeptide repeat protein (UTX) a histone H3 lysine 27 demethylase [43,44].