APP and Alzheimer disease: Compared to C2, FDR-AD PBMCs exhibited lower expression of SREBP-2, Cav-1, nCEH, ABCA-1 as well as BACE-1, APP and neprylisin (Figure 4d), a pattern of gene expression similar to C1 group with the exception of SREBP-2, nCEH and Cav-1 mRNA levels that were significantly (p < 0.05) decreased in FDR-AD compared to C1 (Figure 4e).