BACE1 and Alzheimer disease: In this study, we also showed that in AD-FDR-PBMCs, several cholesterol related genes are regulated in the same direction of those involved in APP processing: lower expression of SREBP-2, Cav-1, nCEH, ABCA1 as well as that of BACE1, APP and neprylisin were observed in AD-FDR compared to C1.