Serum adiponectin levels showed a significant negative correlations with BMI, systolic blood pressure (SBP), diastolic blood pressure (DBP), TG, hsCRP and apolipoprotein B. In addition, serum adiponectin levels demonstrated a significant positive correlations with duration of DM and CAN score. This evidence concerns the gene ADIPOQ and Crouzon syndrome-acanthosis nigricans syndrome.