HTT and Huntington disease: Additionally, several modules were annotated for genes of interest in HD such as druggable genes (as notably observed in the modules for suppression of 128Q-neuron dysfunction by RNAi; see Additional file 9: Table S8), htt partners, and genes involved in autophagy, mitochondrial function and synaptic activity, which further illustrated the relevance of our dataset to neuroprotective target discovery in HD.