A multivariate model designed to assess an independent prognostic significance of variables of potential importance for LRC initially incorporated several factors, including expression of PTEN, EGFR, nm23, Ki-67, p-53, and cyclin D1; clinical variables such as age, gender, performance status, tumor site; and classical pathological risk factors, such as neck node involvement, margins, and tumor grade. This evidence concerns the gene CCND1 and neoplasm.