PIM1 and hematopoietic and lymphoid cell neoplasm: Consistent with this model, overexpressing Pim-1 from an immunoglobulin enhancer induces lymphomas in transgenic mice [17], and elevated Pim-1 levels have been associated with development of hematopoietic cancers as well as aggressive tumors of the stomach and prostate [16], [18]–[21].