Importantly, we found that treatment of cells with isoflaone or BR-DIM decreased the expression of miR-92a and attenuated the induction of miR-92a expression stimulated by RANKL in PCa cells (Figure 7A), suggesting a mechanistic link between RANKL, miR-92a and the biological activity of isoflavones or BR-DIM. Here, TNFSF11 is linked to posterior cortical atrophy.