Moreover, isoflavone and BR-DIM regulated the molecules in the signal transduction networks with down-regulation of Akt, NKX3-1, STK-4, CDK13 and MITF (Figure 5C, 5D and Table 1), leading to the inhibition of osteoclastogenesis and PCa growth. The gene discussed is NKX3-1; the disease is posterior cortical atrophy.