TERT and lung adenocarcinoma: For example, the most frequently altered region detected in our 69 tumors was gain of 5p15.32-15.33 (51% of tumors), which harbors the hallmark cancer gene TERT. Gain of 5p was also the most common genomic alteration observed by Weir et al. in a collection of over 350 lung adenocarcinoma tumors [22].