Interestingly, serum levels of miR-571 were significantly correlated with biomarkers of liver synthesis capacity such as pseudocholinesterase (PCHE), prothrombin time, international normalized ratio (INR) or coagulation factor V activity (Data S1), raising the possibility that this distinct miRNAs could serve as a novel serum biomarker reflecting disease severity in liver cirrhosis. The gene discussed is F2; the disease is cirrhosis of liver.