Moreover, transfection of HuH-7 and LX-2 cells, cell lines representing human hepatocytes or HSC, respectively, with miR-571 led to a moderate, but significant down-regulation of CREBBP on RNA level (Figure 5 D), suggesting that CREBBP might be one possible target gene mediating miR-571-dependent effects in the regulation of liver cirrhosis. This evidence concerns the gene CREBBP and cirrhosis of liver.