TFs corresponding to the TFBSs found enriched within CGIs having steady or high starting methylation levels (i.e., stochastically hypomethylated and heritable highly methylated loci) included TFs associated with tissue-specific differentiation (myogenic factors, including MYOD1, MYOG, MYF5, and MYF6), RAR family genes (encoding mediators of differentiation of multiple tissue stem cells), oxidative response genes (NFE2, NFE2L2), and tumor suppressors often downregulated by DNA methylation in various cancers, including TFAP2A, TFAP2B, and TFAP2C (Table 3). The gene discussed is TFAP2C; the disease is cancer.