Interestingly, the gene encoding for tumor necrosis factor (ligand) superfamily member 10 (TNFSF10), a protein that induces apoptosis in transformed and tumor cells, was found to be downregulated in the 4 cell lines, even though the gene was recurrently gained (MRR 3-13; Figure 6B). The gene discussed is TNFSF10; the disease is neoplasm.