The major aim of the present study was to determine the anticancer effect of Aronia melanocarpa fruit juice, a rich source of polyphenols (7.15 g/L), on the acute lymphoblastic leukemia Jurkat cell line, which is deficient for p53 [34], and, if so, to characterize the mechanism involved and to identify active polyphenols involved in the AMJ-induced effects. The gene discussed is TP53; the disease is acute lymphoblastic leukemia.