The term “resistant ovary syndrome” (ROS) is typically used to describe women with primary or secondary amenorrhea, elevated circulating endogenous FSH and luteinizing hormone (LH) levels, 46, XX karyotype, intact uterus and vagina, absence of concomitant autoimmune disease, and presence of numerous primordial follicles as evident in ovarian biopsy [3]. Here, BRD2 is linked to amenorrhea.