In one GWAS, PLCE1 rs2274223 was reported to be associated with risk of both esophageal squamous cell carcinoma and gastric cardia adenocarcinoma in northern Chinese populations [13], and the other GWAS reported a similar finding in ethnic Chinese populations in other geographic areas [14], in which an association was found only in gastric cardia adenocarcinoma but not gastric noncardia adenocarcinoma. This evidence concerns the gene PLCE1 and gastric cardia adenocarcinoma.