Consistently, we found that PLCE1 rs2274223 variant G allele was significantly associated with an increased risk of gastric cancer (the pooled OR = 1.43; 95% CI = 1.29–1.58 for the AG genotype and OR = 2.00; 95% CI = 1.62–2.46 for the GG genotype, compared with the AA genotype) based on 7115 cases and 16201 controls in our pooled analysis. Here, PLCE1 is linked to gastric cancer.