PLCE1 and gastric cancer: To test this hypothesis, in addition to the reported rs2274223A>G, we also selected another potentially functional SNP rs11187870G>C in the 3′UTR miRNA binding site of PLCE1 identified by HapMap and SNPinfo (http://snpinfo.niehs.nih.gov/), which is in incomplete linkage disquilibrium (LD) with rs2274223 (r2 = 0.65, D' = 0.92) as well as in high LD with three of the novel SNPs revealed in GWAS of gastric cancer (rs753724 G>T, r2 = 0.823; rs11187842 C>T, r2 = 0.823; rs3781264 T>C, r2 = 0.823) [14].