The GWAS and replication samples also showed combined genome-wide significant evidence for association at 8q21.11 that spans a number of genes, including RPL7 and KCNB2. RPL7, ribosomal protein L7, has been established as an autoantigen representing a frequent target for autoantibodies from patients with systemic autoimmune diseases, such as systemic lupus erythematosus and rheumatoid arthritis [28]. The gene discussed is KCNB2; the disease is rheumatoid arthritis.