In this study, we found that in 45 children diagnosed with aHUS, genetic disorders in complement-regulating genes encoding CFH, CFI, MCP, CFB, C3, and THBD, as well as the presence of αFH with or without a homozygous deletion in CFHR1/3, are linked with clinical presentation, treatment, and outcome. The gene discussed is CFHR1; the disease is hereditary disease.