In the present retrospective study, we investigate the expression, at histologically-negative resection margins of primary OSCCs, all of the three oral cancer-associated SIBLINGs (BSP, OPN, DSPP) as well as three MMPs (MMP-2, MMP-3, and MMP-9) and correlate expression with the clinical outcome parameters, recurrence and survival. The gene discussed is SPP1; the disease is lip and oral cavity carcinoma.