Validation of the anti-Ro52 QLIPS test showed 66% sensitivity and 100% specificity and has the potential to be adapted for point-of-care evaluation of patients with SjS and other rheumatologic diseases [104].The need for biopsy looking for lymphocytic infiltration of salivary glands should be reduced and in any case is inaccurate in elderly patients [105]. This evidence concerns the gene TRIM21 and Schwartz-Jampel syndrome.