Several possible cardio-protective effects were proposed, including augmenting vascular endothelial growth factor (VEGF) expression, promoting angiogenesis, recovering the normal expressions of sarco/endoplasmic reticulum ATPase 2a and phospholamban, and inhibiting the activation of platelet during myocardial ischemia and reperfusion [16-20]. The gene discussed is VEGFA; the disease is myocardial ischemia.