Nevertheless, atopic disorders are complex diseases that involve interactions among several physiological systems, skin, lung, mucosae, and the immune system and are also present in the elderly and seems that immunosenescence does not affect increased IgE levels in atopic patients with AD and/or high serum IgE levels indicating that in these subgroups of patients the atopic propensity remains into advanced age [13]. Here, IGHE is linked to Alzheimer disease.