For example thrombospondin-1 (THBS1) [63-65], phosphatases (DUSP1) [45], plasminogen activator, urokinase receptor (PLAUR) [60], cadherins (DSC2) [66,67] and zinc finger proteins (ZNF207) [68-71] have been implicated in vascular homeostasis and pathophysiology of PAD. This evidence concerns the gene THBS1 and peripheral arterial disease.